Informatics Publishing Limited

Shreekantiah Umesh , Vinod Kumar Sinha

Abstract

Obsessive compulsive disorder (OCD) is a chronic neuropsychiatric disorder whose pathophysiology is linked to serotonergic dysfunction. More recently, the role of glutamate has also been posited. Lithium is used as an adjunctive for the treatment of OCD which is found to enhance serotonergic transmission. We present a case of OCD who was on stable dose of sertraline developed exacerbation of obsessive compulsive symptoms with acute high dose of lithium but improved after dose reduction.

Keywords

Glutamate, lithium, obsessive compulsive disorder

Full Text

     

Sai Krishna Tikka , Alok Pratap , Vinod Kumar Sinha

Abstract

Second‑generation antipsychotics (SGA), mainly clozapine have been reported to induce myoclonus. Although olanzapine‑induced myoclonus is reported, dose‑dependent response has not been described. We report dose‑related olanzapine‑induced myoclonus in an early onset schizophrenia patient. We also suggest certain management strategies for such adverse side effects.

Keywords

Dose‑dependent, myoclonus, olanzapine

Full Text